ACE Inhibitor Angioedema: What You Need to Know
When working with ACE inhibitor angioedema, a sudden swelling of the face, lips, tongue or throat triggered by ACE inhibitor drugs. Also known as ACE‑I induced angioedema, it can get serious fast and needs immediate attention.
ACE inhibitors are medicines that lower hypertension, high blood pressure by relaxing blood vessels. The downside is that they block the breakdown of bradykinin, a peptide that widens vessels. Too much bradykinin opens the doors for fluid to leak into deeper layers of skin and tissue, which is exactly what creates the swelling we call angioedema. Because of this link, ACE inhibitor angioedema often forces doctors to stop the drug and look for a safer option. One common alternative is the class of ARBs, or angiotensin II receptor blockers, which control blood pressure without raising bradykinin levels.
If you notice tightness in the throat, rapid swelling of the lips, or an unfamiliar puffiness around the eyes after starting an ACE inhibitor, treat it as an emergency – call 999 or head to the nearest hospital. Discontinuing the culprit drug, getting antihistamines or steroids, and possibly switching to an ARB are the typical steps. Knowing the risk factors – such as a family history of angioedema, smoking, or concurrent use of NSAIDs – can help you and your doctor decide whether an ACE inhibitor is worth the gamble. Below you’ll find a curated set of articles that walk through diagnosis, emergency care, and medication alternatives, giving you practical tips you can apply right away.
